DPH potentiates DXM?

[Evaunit001]

Okay, so I was just reading Wikipedia about the CYP2D6 allele (yeah, I'm bored ), and I saw something quite interesting: apparently Diphenhydramine (DPH) acts as an inhibitor of CYP2D6 activity. And we all know that CYP2D6 plays a large part in metabolizing DXM. So...is DPH a potentiator of DXM (sure looks like it)!? Mabye this is common knowledge, but I hadn't heard about it. If I take like 75mg of DPH, will I trip harder / longer off DXM? Like as if I had the CYP2D6 defficiency? Anybody ever tried it? Sounds pretty cool.

Ps. I'm curious about lower doses of DPH with DXM, as I wouldn't really want to reach a DPH trip, just potentiate the DXM.

[Trick]

By DPH, I'm guessing you mean Diphenhydramine...

If so, there are a few reports of Diph mixed with DXM on Erowid and they seem to indicate that you will have more OEV's. But, I think you might have to take more than 75mg.

[Evaunit001]

Yeah, I meant Diphenhydramine. As I recall, all the reports I read on Erowid were talking about taking trip-worthy amounts of DPH (like, >300mg) with the DXM, but that was like 6 months ago when I looked. I just figured those folks had a "double fry" thing going on from a dissociative mixed with a dileriant. I'll have another look. I'm very curious about lower (non-trippy) doses of DPH potentiating DXM.

[T-Wrecks]

dont waste a good dex trip with delerients most are just anticholine

[Evaunit001]

I definitely wouldn't want to mix trips, but I am fascinated by the action of DPH on the P450 enzymes (the CYP2D6 allele in particular, obviously). If I could take, say half the dose of dex and still get the same effect, or take a regular dose but have it last twice as long, just from popping a few Benadryl, then damn right I'm going to!

[Trick]

I'm going to try 600mg of DXM and 100mg of Diph tonight, I'll let you know if it makes a difference.

[false]

From my personal Diph and Dex experiences I wouldn't want to mix them, even if Diph acted as a potentiator. Other than that though, if it works for you guys (non-placebo as well) then go for it. DXM is already crazy enough without you having to question whether you are real and all.

[Evaunit001]

Yeah, that's why I mentioned being curious about non-trippy doses of DPH. I don't wat to trip on DPH while I'm tripping on DXM. As I stated initially, I'm curious about the possibility of DPH as a potentiator of DXM at levels too low to cause a DPH trip, but high enough to extend / enchance the DXM. WP says that DPH is a P450 (CYP2D6) antagonist; that means that it should potentiate DXM. To me that sounds like the win.

Ps. Alright Trick, looking foward hearing how it went.

[Ollie]

Eva: I don't understand why you'd choose to go that route over simple grapefruit juice. Do you have a preference to doing it this way? It just seems like it's less variables with the juice.

[sleepwalkin']

I've done that before. I took dramamine and DXM and weed. I had OEV's. I thought I was at a Led Zeppelin concert

[HeroInTheHat]

What happened to plain ol' good pure dexing? Redose, redose, and redose ladies and gentlemen.

[KXT]

I thought I was at a Led Zeppelin concert

LMFAO!! >__<

I remember one of the first few times I did DXM I thought I was In hell raving with a dead friend and some zombies and shit. I fucking Loved it. Its like Satan was holding a Ball for all these bad ass mother fuckers. I was so happy.

What happened to plain ol' good pure dexing? Redose, redose, and redose ladies and gentlemen.

He makes a real point here people.
I always considered I spaced out my doses when taking DXM.
I was wrong.
Dose some about two (if not more) hours before you take more.

I did that the latest time I tripped, and it was my best so far (only on one bottle too [and 4grams of magnesium]).

it works.

[Trick]

Last night was probably one of the craziest trips I've ever had. IMO, Diph does make it stronger. I only took 600mg and I am positive that I hit the 3rd plateau.


7:30 PM - Dosed 300 mg of DXM, 100 mg of Diph, and another 300 mg of DXM.

8:30 PM - Hit me faster than I expected, starts off feeling like a Diph trip. I'm feeling extremely tired, heavy, and I'm seeing black dots all over the wall.

9:00 PM - Can't stand being on he computer anymore, so I head up stairs. I feel like I'm going to pass out any second now. The DXM is starting to take over, I'm having intense head rushes. I make it to my bed and turn the TV on, but its impossible for me to understand what's going on.

9:30 PM - I keep drifting off into my own world. I'm shaking hard and can't keep my hands still. I stumble my way to the bathroom and try to take my contacts out, but my hands won't move.

10:00 PM - I turn the TV and the lights off. I'm starting to become delirious. The room around me keeps changing, I don't know where I am or how to get out. The walls are spinning and morphing into colorful patterns.
I experienced deja vu a lot during this part of the trip. I sit up, open my eyes and realize I'm still laying down, open my eyes and I'm still laying down. This goes on for sometime and I feel like I'm trapped. Eventually, I'm able to come back to this world and try to stand up. No luck, I forget how to walk and have lie back down.

10:30 PM - I start getting extremly paranoid. My mind is racing, I keep thinking I'm hearing an ambulance coming to get me and that I'm going to spend the night in the hospital. Total confusion takes over. Voices in my head are telling me I'm dead, and I start to see white light(I think my fan light turned on by itself ). The light goes away and I'm in a narrow hall way and voices are telling me everything is alright, It's not my fault that I took DXM.

The last time I look at the clock, its 11:00 PM. At this point, I'm passing in and out of consciousness so I only remember bits and pieces which don't make any sense to me.

Woke up this morning still jittery and with a head high. Overall, it was a probably my best DXM experience. The only downside is how drowsy the Diph makes you.

[T-Wrecks]

You will never be able to imagine what has gone thouugh my mind with HIGH doses of dxm and VARIOUS chemicals. I've used. thats. I got lost in my own bathroom, I'll leave it at that.

I didn't use Diph either. just Tussin, Twisted tea, and CVS cough and cold HBP